@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix dt: <http://www.hl7.org/owl/iso-dt-2.0#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix bridg: <http://www.bridgmodel.org/owl#> .
@prefix study1: <http://www.w3.org/2013/12/FDA-TA/tests/RenalTransplantation/study1#> .

@prefix elig: <http://www.w3.org/2013/12/FDA-TA/Eligibility> . # @@ To be created.
@prefix drugs: <http://www.w3.org/2013/12/FDA-TA/drugs#> .

study1:version1 a bridg:StudyProtocolVersion ;
    bridg:StudyProtocolVersion.intendedPlannedStudySubject study1:plannedSubjects ; # inv
    bridg:StudyProtocolVersion.versionedStudyProtocol study1:protocol .

# @@ study1:protocol ...

study1:plannedSubjects a bridg:PlannedStudySubject ;
    bridg:PlannedStudySubject.plannedForStudyProtocolVersion study1:version1 ;
    bridg:PlannedStudySubject.quantityRange [ a dt:URG_INT.POS ] ;
    bridg:PlannedStudySubject.constrainingDefinedEligibilityCriterion study1:eligibility_dialysis .

study1:eligibility_dialysis a bridg:DefinedEligibilityCriterion ;
    # bridg:DefinedEligibilityCriterion.constrainedPlannedStudySubject study1:plannedSubjects # inv
    elig:effectiveDateRange [ a dt:IVL_TS.DATETIME ] ; # @@ 5-15 months
    bridg:DefinedEligibilityCriterion.requiredResponse [ a dt:ANY ] .

study1:arm0 a bridg:Arm ;
    bridg:Arm.name [ a dt:ST ] ; # Control comparitor
    bridg:Arm.containedPlannedActivity study1:prescribeImmunosuppressantA ;
    bridg:Arm.randomizationWeight [ a dt:RTO_INT.NONNEG_INT.POS ] ; # 1(of 3)
    bridg:Arm.targetAccrualNumberRange [ a dt:URG_INT.NONNEG ] ; # 30-35
.

study1:arm1 a bridg:Arm ;
    bridg:Arm.name [ a dt:ST ] ; # Active comparitor
    bridg:Arm.containedPlannedActivity study1:prescribeImmunosuppressantB ;
    bridg:Arm.randomizationWeight [ a dt:RTO_INT.NONNEG_INT.POS ] ; # 2(of 3)
    bridg:Arm.targetAccrualNumberRange [ a dt:URG_INT.NONNEG ] ; # 60-70
.

study1:prescribeImmunosuppressantA a bridg:PlannedActivity ;
    bridg:PlannedActivity.name [ a dt:ST ] ; # prescribe drug A
    bridg:PlannedActivity.purpose [ a dt:ST ] ; # suppress T-cell activity
    bridg:PlannedActivity.usedStudyActivity study1:studyImmunosuppressantA ;
    bridg:PlannedActivity.containingArm study1:arm0 ;
    bridg:PlannedActivity.duration [ a dt:PQ.TIME ] ; # 5 days
    bridg:PlannedActivity.reasonCode [ a dt:DSET_CD ] . # study efficacy of reference Drug A

study1:prescribeImmunosuppressantB a bridg:PlannedActivity ;
    bridg:PlannedActivity.name [ a dt:ST ] ; # prescribe drug B
    bridg:PlannedActivity.purpose [ a dt:ST ] ; # suppress T-cell activity
    bridg:PlannedActivity.usedStudyActivity study1:studyImmunosuppressantB ;
    bridg:PlannedActivity.containingArm study1:arm1 ;
    bridg:PlannedActivity.duration [ a dt:PQ.TIME ] ; # 5 days
    bridg:PlannedActivity.reasonCode [ a dt:DSET_CD ] . # study efficacy of Drug B

study1:studyImmunosuppressantA a bridg:StudyActivity ;
    bridg:StudyActivity.studyFocusIndicator [ a dt:BL ] ; # false
    bridg:StudyActivity.usedDefinedActivity study1:generalPrescriptionOfImmunosuppressantA ;
    bridg:StudyActivity.usingStudyProtocolVersion study1:version1 .

study1:studyImmunosuppressantB a bridg:StudyActivity ;
    bridg:StudyActivity.studyFocusIndicator [ a dt:BL ] ; # true
    bridg:StudyActivity.usedDefinedActivity study1:generalPrescriptionOfImmunosuppressantB ;
    bridg:StudyActivity.usingStudyProtocolVersion study1:version1 .

study1:generalPrescriptionOfImmunosuppressantA a bridg:DefinedSubstanceAdministration ;
    bridg:DefinedProcedure.usedProduct drugs:ImmunosuppressantA ;
    bridg:DefinedSubstanceAdministration.doseFrequencyCode [ a dt:CD ] ; # 4/1.0d
    bridg:DefinedSubstanceAdministration.routeOfAdministrationCode [ a dt:CD ] ; # IV
    bridg:DefinedSubstanceAdministration.usedDefinedExpressionVariableRelationship study1:varQtyOfImmunosuppressantA . # inv

study1:generalPrescriptionOfImmunosuppressantB a bridg:DefinedSubstanceAdministration ;
    bridg:DefinedProcedure.usedProduct drugs:ImmunosuppressantB ;
    bridg:DefinedSubstanceAdministration.doseFrequencyCode [ a dt:CD ] ; # 6/1.0d
    bridg:DefinedSubstanceAdministration.routeOfAdministrationCode [ a dt:CD ] ; # IV
    bridg:DefinedSubstanceAdministration.usedDefinedExpressionVariableRelationship study1:varQtyOfImmunosuppressantB . # inv

study1:varQtyOfImmunosuppressantA a bridg:DefinedExpressionVariableRelationship ; # @@ where to put ".6mg/kg"?
    bridg:DefinedExpressionVariableRelationship.usingDefinedSubstanceAdministration study1:generalPrescriptionOfImmunosuppressantA ;
    bridg:DefinedExpressionVariableRelationship.localVariableName "quantity" ;
    bridg:DefinedExpressionVariableRelationship.referencedDefinedObservation study1:weight .

study1:varQtyOfImmunosuppressantB a bridg:DefinedExpressionVariableRelationship ; # @@ where to put ".9mg/kg"?
    bridg:DefinedExpressionVariableRelationship.usingDefinedSubstanceAdministration study1:generalPrescriptionOfImmunosuppressantB ;
    bridg:DefinedExpressionVariableRelationship.localVariableName "quantity" ;
    bridg:DefinedExpressionVariableRelationship.referencedDefinedObservation study1:weight .

study1:weight a bridg:DefinedObservation ;
    bridg:DefinedActivity.nameCode [ a dt:CD ] . # @@ snomed:weight